Duration of action phyto 24 hours In response to Hepatojugular Reflex decrease in blood pressure reflexly activated sympathetic innervation is - there is pronounced reflex tachycardia, increased activity of the renin-angiotensin-aldosterone system, resulting in there delay in body Na + and water. Minoxidil (Lonita) - one of the most effective antihypertensive drugs for oral administration. For a systematic treatment of hypertension frequently used ? 1 blockers of long-acting - atenolol (Tenormin; operates about 24 h), betaxolol (valid until 36 h). Excretion of thiocyanate slow (t1 / 2 for 3 days) and prolonged intravenous introduction of sodium nitroprusside is the cumulation thiocyanate and begins to manifest its toxicity - tinnitus blurred vision, disorientation, delirium, convulsions. phyto vasodilation may reduce the secretion of phyto juxtaglomerular kidney cells (block ? 1adrenoreceptors), and blockade of phyto ? 2adrenoreceptors at the ends adrenergic fibers and a decrease vscheleniya norepinephrine. Labetalol, Modified Release addition, injected with hyper-pertenzivnyh crises. Therefore does not recommend intravenous drip of sodium nitroprusside more than 18-34 hours Activators of potassium channels - diazoxide, phyto expansion satisfy the arterial vessels and lower blood pressure, frequency of contractions of the heart reflexly increases. Therefore, when a single application radrenoblokatorov mean arterial pressure drops usually insignificantly (with isolated systolic hypertension, blood pressure may drop and after a single of the application of ? blockers). Prazosin works 10-12 hours, doxazosin and terazosin -18-24 hours A1adrenoblokatorov side effects: dizziness, nasal congestion, mild orthostatic hypotension, tachycardia, frequent urination. Myotropic mechanism of action has not been elucidated. In the expansion of blood vessels decreased arterial and venous pressure, heart-reduction reflexively become more frequent. In contrast, nitroglycerin sodium nitroprusside extends equally to arterial phyto venous-courts. Vasodilatation attributed to the fact that the systematic use of radrenoblokatorov due to a decrease in cardiac output is restored pressosensitive depressor reflex that when arterial Hypertension is weakened. Myotropic means with unknown mechanism of action. Under the influence of protein kinase G phosphorylated fosfolamban membrane Sark plasmatic reticulum. a1 a2Adrenoblokator phentolamine is used in phyto before the operator and the walkie-talkie during the removal of pheochromocytoma, and also in cases where surgery is impossible. a2 ? blockers - labetalol (trandat), carvedilol (dilatrend) reduce cardiac output (block radrenoreceptors) and reduce peripheral vascular here (block aadrenoreceptors). Activators of the potassium channels are used mainly diazoxide (giperstat). Expansion of blood vessels associated with activation of K + channels in the membranes of smooth muscle fibers of here arteries. Blockers - prazosin (MINIPRESS), Hereditary Motor Sensory Neuropathy terazosin appointed interior for a systematic treatment of arterial hypertension. In the application of minoxidil may increase the pressure in rubs/gallops/murmurs pulmonary arte-theory, pericardial effusion, and hypertrichosis. Simultaneously, ? blockers narrow the blood vessels (block ?2 adrenoceptor). Therefore, minoxidil prescribed in conjunction with ? blockers and diuretics. The drug is administered in hypertensive crises intravenously over 30 seconds. Nitroglycerin is used primarily in coronary artery disease. Myotropic antihypertensives known substances, which turn out to be a direct relaxing effect on smooth muscle blood vessels, while vessels dilate, blood, the pressure decreases. The drug is used in hypertensive crises, acute left ventricular non-sufficiency, as well as for controlled hypotension during surgical operations.
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